Abstract: Aiming at the problem that the characteristics of villages and towns are not enough, this paper puts forward the technical achievements framework and the overall spatial framework for constructing the guidance system of characteristic villages and towns' spatial gene inheritance and planning design, based on open framework of ‘overall framework + regional guidance’ proposed by Duan Jin et al. Focusing on the characteristic villages and towns, this paper analyzes the spatial element combination rules and its formation mechanism of regional characteristics from the three spatial levels of landscape, settlement and architecture, proposes the spatial gene inheritance and planning guidance, and takes the guidelines for the characteristic villages and towns at the southwest foot of the Nishan Hilly Area in Southern Shandong Province as an example to introduce the main contents of this level in detail.